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The combined treatment of sCT and liraglutide, especially when administered in a stepwise manner, produced greater body weight loss, reduced adiposity and decreased plasma leptin levels compared to individual monotherapies and vehicle in DIO rats

Finally, beyond their role in controlling metabolic processes, GLP-1 receptor agonists also show promising potential benefits in treating cardiovascular and neurodegenerative diseases

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Medication review is essentialdose reduction or temporary discontinuation may be necessary if side effects are severe, and concurrent medications (particularly insulin or sulfonylureas) may require adjustment